Binding of Isaac does not have a built-in controller support, and you can try using this controller support config with reWASD!
First of all, there are a few things you'd better find out before you try reWASD. That's how it works: the software uses emulated keyboard and mouse, and the first thing you need to do is to add keyboard mappings to controller buttons. Once the configuration is applied, all the assigned keyboard bindings will reproduce after the controller buttons are pressed.
Specifically for this config: since Binding of Isaac doesn't have controller support at all, all you need to do is to add keyboard mappings, and the config is ready. We used the default in-game controls scheme for making this config, so if you have modified the layout you need to whether reset to default or change the bindings inside the config according to your in-game settings. You can modify the config if you need to :)
Seems like you're ready to try out how this controller support profile works! There are a few steps you need to complete to enable this config:
Done! Now you can launch the game and play with the controller :)
Check out the other Binding of Isaac configs in our community.