I've done 2 titles with cocos2d JS so far, it is easy to use and even highly customisable. Sometimes there are limit glitch and limitation but as its open source, dev will be able to modify the source c++ code. And lots of resources online to assist. JSB is really a time saver for multi platform mobile developments.
The only downside I have faced is the lack of documentation, although right now the developers are putting up a great wiki. I myself struggled a lot during the learning phase.
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